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25.ΪʲôҪԤⰫ߶ͯƹеӦ

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    ǽ¹׼-йǷ׼-л05ϵµĵ25ƪԤⰫ߶ͯƹӦıҪԡ

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¼ڣ2010/3/3

    GH߰߶ͯٶȺѱοо֤ʵһԹ̶GH3-7꣬߱Ԥij1SDWit et al.[1]оGHط԰߶ͯߺǰٶȵӰ졣˷Ϊ0.24 mg/kg/ܼ飻һ0.24 mg/kg/ܣȻ0.37 mg/kg/ܼ飻0.37 mg/kg/ܵļ顣720.37 mg/kg/ܵIJٶ70ܼ0.24 mg/kg/ܵIJˣЧ= 0.8 cm/; P = .003) Ҳ670.24-->0.37 mg/kg/ܼ鲡 (Ч= 0.9 cm/; P = .001) 50ߵIJУƽ߷ֱ1.551.521.85 SDS0.37 mg/kg/ܺ0.24 mg/kg/ܼ֮䣬Ч0.57SD3.6cmP=.025ƽ߾߼ȥԤߣֱΪ7.2cm5.4cmˣط԰߶ͯGHٶȺ߾мԡ1GHʱٶҲӡ

    ȻGHԣǽͬGHĶͯҲɼӦĿ졣ٶȶͯGHϵоʾGHˮƽ֮ءֹܴϵٶƶͯ۲쵽ΧѪGHˮƽʾGHķӦڲ졣ˣڶͯ˵GHںGHӦҪһЩԴأŴ̬ԡŴ쳣ǰ/ڵĴл仯ӰGHںӦ֮ƽ⡣

    ˣʶڷѧݶGHƵӦƶ廯ƷĽ飬ݴݽ˲ͬ߶ͯԤӦģͨ͡ʹЩԤģͿʹGHƼѻ[2]Kristrom et al.[3]153ΪȱGHDط԰ߣISSͯȽ˱׼ԤģͶȷĸ廯GHӦԲSDS常ĸֵSDSMPH SDS֮ diffMPHSDSΪָꡣо廯diffMPHSDSΧȱ׼С32%P < 0.003ƽdiffMPHSDSƣֱΪ0.420.46 0.480.67GHȱISSͯGH0-2SDSҲƣֱΪ1.310.47 1.360.47ˣóڿʼGH ƺĸڼ䣬廯GHС˴ﵽԤĿû򻵵ĶͯıСӦĿɱԡ

    ԣݻѧأԤ尫߶ͯƹеӦȷﵽԤĿĶӦõGHƼƹиӦԤƷ

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[1] Wit JM, Rekers-Mombarg LT, Cutler GB, et al. Growth hormone (GH) treatment to final height in children with
    idiopathic short stature: evidence for a dose effect. J Pediatr, 2005, 146(1):45-53.

[2] Keni J and Cohen P. Optimizing Growth Hormone Dosing in Children with Idiopathic Short Stature. Horm Res
     2009;71(suppl 1):70C74

[3] Kristrom B, Aronson AS, Dahlgren J, et al. Growth Hormone (GH) Dosing during Catch-Up Growth Guided by
     Individual Responsiveness Decreases Growth Response Variability in Prepubertal Children with GH
     Deficiency or Idiopathic Short Stature. J Clin Endocrinol Metab, 2009, 94:483C490.


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