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רҵĹ׼Ӧ÷ṩ ʺ϶ͯĹ;ʹ¹׼Ĺ,׼ȷԤ ¹׼л-05 ׼ӦԼԤķ֧ ӦáԤ ׼ѧѧоɹ רҵĹ׼Ӧ÷ṩ ϵ
    ע2006꣬ʺϵйͯĹ׼л-05桶йǷ׼CHNTY/T 001-1992Ϊл񹲺͹ҵ׼
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25.ΪʲôҪԤⰫС֢ͯƹеӦ

ժҪ

    ǽ¹׼-йǷ׼-л05ϵµĵ25ƪԤⰫС֢ͯƹӦıҪԡ

ؼʣ

С֢,,GH

ߣվԭ
ߵλ˶
¼ڣ2010/3/3

    (GH)߰С֢ͯٶȺѱοо֤ʵһԹ̶(GH)3-7꣬߱Ԥij1SDWit et al.[1]о(GH)ط԰С֢ͯߺǰٶȵӰ졣˷Ϊ0.24 mg/kg/ܼ飻һ0.24 mg/kg/ܣȻ0.37 mg/kg/ܼ飻0.37 mg/kg/ܵļ顣720.37 mg/kg/ܵIJٶ70ܼ0.24 mg/kg/ܵIJˣЧ= 0.8 cm/; P = .003) Ҳ670.24-->0.37 mg/kg/ܼ鲡 (Ч= 0.9 cm/; P = .001) 50ߵIJУƽ߷ֱ1.551.521.85 SDS0.37 mg/kg/ܺ0.24 mg/kg/ܼ֮䣬Ч0.57SD3.6cmP=.025ƽ߾߼ȥԤߣֱΪ7.2cm5.4cmˣط԰С֢ͯ(GH)ٶȺ߾мԡ1(GH)ʱٶҲӡ

    Ȼ(GH)ԣǽͬ(GH)ĶͯҲɼӦĿ졣ٶȶͯ(GH)ϵоʾ(GH)ˮƽ֮ءֹܴϵٶƶͯ۲쵽ΧѪ(GH)ˮƽʾ(GH)ķӦڲ졣ˣڶͯ˵(GH)ں(GH)ӦҪһЩԴأŴ̬ԡŴ쳣ǰ/ڵĴл仯Ӱ(GH)ںӦ֮ƽ⡣

    ˣʶڷѧݶ(GH)ƵӦƶ廯ƷĽ飬ݴݽ˲ͬС֢ͯԤӦģͨ͡ʹЩԤģͿʹ(GH)Ƽѻ[2]Kristrom et al.[3]153Ϊȱ(GH)Dط԰С֢ISSͯȽ˱׼ԤģͶȷĸ廯(GH)ӦԲSDS常ĸֵSDSMPH SDS֮ diffMPHSDSΪָꡣо廯diffMPHSDSΧȱ׼С32%P < 0.003ƽdiffMPHSDSƣֱΪ0.420.46 0.480.67(GH)ȱISSͯ(GH)0-2SDSҲƣֱΪ1.310.47 1.360.47ˣóڿʼ(GH) ƺĸڼ䣬廯(GH)С˴ﵽԤĿû򻵵ĶͯıСӦĿɱԡ

    ԣݻѧأԤ尫С֢ͯƹеӦȷﵽԤĿĶӦõ(GH)ƼƹиӦԤƷ

ο

[1] Wit JM, Rekers-Mombarg LT, Cutler GB, et al. Growth hormone ((GH)) treatment to final hei(GH)t in children with
    idiopathic short stature: evidence for a dose effect. J Pediatr, 2005, 146(1):45-53.

[2] Keni J and Cohen P. Optimizing Growth Hormone Dosing in Children with Idiopathic Short Stature. Horm Res
     2009;71(suppl 1):70C74

[3] Kristrom B, Aronson AS, Dahlgren J, et al. Growth Hormone ((GH)) Dosing during Catch-Up Growth Guided by
     Individual Responsiveness Decreases Growth Response Variability in Prepubertal Children with (GH)
     Deficiency or Idiopathic Short Stature. J Clin Endocrinol Metab, 2009, 94:483C490.


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